A Multimodal Approach to Improve Detection of Atrial Fibrillation after Stroke (MAP-AFDAS)

Unraveling the phenomenon of AF detected after stroke

About our Findings

Atrial fibrillation (AF) is the most common cause of ischemic stroke. In many cases, it is only detected after stroke during cardiac monitoring or Holter ECG (AF detected after stroke – AFDAS). Some stroke-related factors might even precipitate AF: for instance, strokes in the insula, a brain region related to the regulation of the autonomous nervous system, are strongly associated with the detection of AFDAS – an intriguing finding that highlights how brain-related factors can greatly influence cardiac outcomes.

Funded by German Heart Foundation

To further investigate this relationship, the #BrainHeartLab obtained funding from the German Heart Foundation. We will employ a multimodal approach using neuroimaging, cardiac monitoring data from our stroke units and Machine Learning to unveil patterns that could potentially precipitate AFDAS and help clinicians by guiding treatment decisions.

Clinical Studies

  • MAP-AFDAS (funded by Deutsche Herzstiftung)
  • AF Burden during hospitalization for acute stroke
  • Comparison of ECG-detected and PCM-detected AF. 

Collaborators

We are happy to collaborate with the Group Computational Neurology headed by PD. Dr. Christian Meisel and to work with monitoring data from the BrainLab Data Warehouse connect system (NeuroCure Cluster of Excellence)

Related Publications

  • Scheitz et al, Stroke 2015 (DOI: 10.1161/STROKEAHA.115.008681)
  • Klammer et al, JAHA 2024 (doi: 10.1161/JAHA.124.035285)
  • doi: 10.1177/17474930241312649.
  • doi: 10.1016/j.heliyon.2023.e18432.
  • doi: 10.1136/jnnp-2021-328391.
  • doi: 10.1016/j.ebiom.2025.105869.

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